| Autor: |
Fellows, Gillian, Gittoes, N., Scott, D. G. I., Coppock, J. S., Wainwright, A., Goodall, Margaret, Turner, B. M. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jun1988, Vol. 72 Issue 3, p440-445, 6p |
| Abstrakt: |
Using a solid-phase radioimmunoassay we have measured levels of anti-histone autoantibodies of the IgG, IgA and IgM heavy chain classes in 40 patients with systemic lupus erythematosus. Twenty-two patients (55%) had significantly elevated levels of at least one anti-histone isotype. Our results reveal four characteristics of the anti-histone response. (1) There is wide variation between patients in the isotype profile of anti-histone antibodies and these isotype profiles are a consistent individual characteristic. (2) There is no significant correlation between the levels of IgG, IgA and IgM antihistone in individual patients and a marked tendency for a single isotype (either IgG, IgA or IgM) to predominate in any one patient. (3) IgG anti-histone antibodies are predominantly of the IgGl subclass. (4) Among 12 patients tested, IgG and IgA antibodies showed a preference for histones 1 and 2B whereas IgM antibodies sbowed no consistent preference for individual histones. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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