ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. Biological and clinical findings.

Autor: Chiaretti, Sabina, Taherinasab, Akram, Della Starza, Irene, Canichella, Martina, Ansuinelli, Michela, De Propris, Maria Stefania, Messina, Monica, Spinelli, Orietta, Santoro, Alessandra, De Novi, Lucia Anna, Cardinali, Deborah, Schipani, Mattia, Arena, Valentina, Bassan, Renato, Guarini, Anna, Foà, Robin
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Zdroj: Leukemia & Lymphoma; Feb2023, Vol. 64 Issue 2, p483-486, 4p
Abstrakt: The median age of I ZNF384-r i patients was 43 years (range 18-64), 47% were female and 53% male; the median WBC count was 4.82 × 10 SP 9 sp /L (range 1-54.9), while the median platelet count was significantly higher in I ZNF-384 i -r patients compared to the remaining cases (176 B × b 10 SP 9 sp /L vs 49 × 10 SP 9 sp /L, I p i <.001) (Table S2, Supplemental Material). We identified 17 (9.2%) patients with I ZNF384- i r, involving different partner genes: the most frequent fusion was I ZNF384-EP300 i ( I n i = 9), followed by I ZNF384-TAF15 i ( I n i = 4) I ZNF384-TCF3 i ( I n i = 2) and I ZNF384-ARID1B i ( I n i = 1). Rearrangements involving I ZNF384 i ( I ZNF384-r i ) were described in B/myeloid mixed phenotype acute leukemia (B/MPAL) [[9]] and in Ph- B-ALL; in the latter, at least 15 partner genes were identified ( I EWSR1 i , I TAF15 i , I TCF3 i , I EP300 i , I SYNRG i , I CREBBP i , I BMP2K i , I SMARCA2, CLLORF74, CCAR1, CLTC, DUX4, NIPBL, SEC24B and ARID1B i ) [[10]]. ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. [Extracted from the article]
Databáze: Complementary Index
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