Response to "Plasma Uracil as a DPD Phenotyping Test: Pre‐analytical Handling Matters".

Autor: de With, Mirjam, Knikman, Jonathan, Schellens, Jan H. M., Gelderblom, Hans, Cats, Annemieke, Guchelaar, Henk‐Jan, Mathijssen, Ron H. J., Swen, Jesse J., Meulendijks, Didier
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Zdroj: Clinical Pharmacology & Therapeutics; Mar2023, Vol. 113 Issue 3, p473-475, 3p
Abstrakt: Response to "Plasma Uracil as a DPD Phenotyping Test: Pre-analytical Handling Matters" (b) Comparison of uracil concentration between patients experiencing no severe toxicity (grade 0-2) and patients who did experience severe toxicity (grade 3-5) excluding the six hospitals with the highest median uracil concentrations. We thank Thomas I et al i . for the comments on our publication[1] and continued discussion regarding the feasibility and clinical validity of plasma uracil concentration as a marker for DPD deficiency. [Extracted from the article]
Databáze: Complementary Index