| Autor: |
Mithraprabhu, Sridurga, Reynolds, John, Turner, Rose, Quach, Hang, Horvath, Noemi, Kerridge, Ian, Kalff, Anna, Bergin, Krystal, Hocking, Jay, Yuen, Flora, Khong, Tiffany, Durie, Brian M., Spencer, Andrew |
| Předmět: |
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| Zdroj: |
Blood Cancer Journal; Jan2023, Vol. 13 Issue 1, p1-5, 5p |
| Abstrakt: |
We and others have demonstrated that circulating cell-free tumour DNA (ctDNA) analysis is rapidly emerging as a robust non-invasive adjunct to bone marrow (BM) biopsy, in this spatially heterogenous disease, for comprehensive genomic analysis, therapeutic monitoring and defining the underlying biology of resistance in MM (reviewed in ref. [[5]]). This analysis utilised equal numbers of patients for BM and ctDNA analysis. A chi-square test for relative proportions of patients with specific ctDNA mutations (>1% VAF) also identified a statistically significant difference between relapse and non-relapse for I RAS/RAF i (22.2% vs 3.4%, I P i = 0.04) and DDR (55.5% vs 20.6%, I P i = 0.01) (Fig. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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