| Autor: |
Perera, Marianne R, Greenwood, Edward J D, Crozier, Thomas W M, Elder, Elizabeth G, Schmitt, Janika, Crump, Colin M, Lehner, Paul J, Wills, Mark R, Sinclair, John H, Collaboration, the Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research COVID BioResource, Greenwood, Edward Jd, Crozier, Thomas Wm |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 2/15/2023, Vol. 227 Issue 4, p543-553, 11p |
| Abstrakt: |
SARS-CoV-2, the causative agent of COVID-19, has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection with human cytomegalovirus (HCMV) substantially increases infection with SARS-CoV-2 in vitro. HCMV is a common herpesvirus carried by 40-100% of the population which can reactivate in the lung under inflammatory conditions, such as those resulting from SARS-CoV-2 infection. We show in both endothelial and epithelial cell types that HCMV infection upregulates ACE2, the SARS-CoV-2 cell entry receptor. These observations suggest that HCMV reactivation events in the lung of healthy HCMV carriers could exacerbate SARS-CoV-2 infection and subsequent COVID-19 symptoms. This effect could contribute to the disparity of disease severity seen in ethnic minorities and those with lower socio-economic status, due to their higher CMV seroprevalence. Our results warrant further clinical investigation as to whether HCMV infection influences the pathogenesis of SARS-CoV-2. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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