Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland.

Autor:	Kania, Michał, Mazur, Konrad, Terlecki, Michał, Matejko, Bartłomiej, Hohendorff, Jerzy, Chaykivska, Zlata, Fiema, Mateusz, Kopka, Marianna, Kostrzycka, Małgorzata, Wilk, Magdalena, Klupa, Tomasz, Witek, Przemysław, Katra, Barbara, Klocek, Marek, Rajzer, Marek, Malecki, Maciej T.
Předmět:	INSULIN therapy LENGTH of stay in hospitals C-reactive protein DIURETICS CHRONIC kidney failure STATINS (Cardiovascular agents) ANTIHYPERTENSIVE agents COVID-19 ACADEMIC medical centers MULTIPLE regression analysis CALCIUM antagonists DIABETES HEALTH outcome assessment ACQUISITION of data HYPOGLYCEMIC agents RETROSPECTIVE studies RISK assessment HOSPITAL mortality ARTIFICIAL respiration SYMPTOMS HOSPITAL care MEDICAL records DESCRIPTIVE statistics CRITICAL care medicine RESEARCH funding LONGITUDINAL method FIBRIN fibrinogen degradation products HEART failure
Zdroj:	International Journal of Endocrinology; 2/16/2023, p1-11, 11p
Abstrakt:	Background. Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods. The data analysis of patients admitted between March 6, 2020, and May 31, 2021, to the University Hospital in Krakow (Poland), a reference center for COVID-19, was performed. The data were gathered from their medical records. Results. A total number of 5191 patients were included, of which 2348 (45.2%) were women. The patients were at the median age of 64 (IQR: 51–74) years, and 1364 (26.3%) were DPs. DPs, compared to nondiabetics, were older (median age: 70 years, IQR: 62–77 vs. 62, IQR: 47–72, and p < 0.001) and had a similar gender distribution. The DP group had a higher mortality rate (26.2% vs. 15.7%, p < 0.001) and longer hospital stays (median: 15 days, IQR: 10–24 vs. 13, IQR: 9–20, and p < 0.001). DPs were admitted to the ICU more frequently (15.7% vs. 11.0%, p < 0.001) and required mechanical ventilation more often (15.5% vs. 11.3%, p < 0.001). In a multivariate logistic regression, factors associated with a higher risk of death were age >65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. Conclusion. In this large COVID-19 cohort, DPs constituted more than a quarter of hospitalized patients. The risk of death and other outcomes compared to nondiabetics was higher in this group. We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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