| Autor: |
Sumazaki, R., Fujita, T., Kabashima, T., Nishikaku, F., Koyama, A., Shibasaki, M., Takita, H. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Oct1986, Vol. 66 Issue 1, p103-110, 8p |
| Abstrakt: |
Monoclonal antibodies to bacterial lipopolysaccharide (LPS) were prepared by fusing spleen cells from BAI.B/c mice immunized with Salmonella Minnesota Rc 595 LPS to the mouse myeloma cell line P3U1. One of them designated RS01 revealed a strong positive antinuclear activity and reacted with DNA-histone. RS01 also bound specifically lo Salmonella Minnesota Re 595 LPS and eliminated the histological activity of LPS. The Salmonella completely inhibited the ANA activity of RSOI and DNA-histone blocked the reactivity of RS01 with LPS. Thus, it is clear that an anti-LPS monoclonal antibody. RS01 cross-reacts with DNA-histone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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