Association Between Dosimetric and Toxicity Findings Using Hypo-Fractionated Whole Breast Radiotherapy: A Long-Term Experience.
| Autor: | Eren, Ayfer Ay, Goksel, Evren, Umay, Cenk, Eren, Mehmet Fuat, Bese, Nuran |
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| Předmět: |
BREAST cancer prognosis
ULTRASONIC imaging of the abdomen AESTHETICS LOG-rank test MULTIVARIATE analysis RADIODERMATITIS HYPEREMIA MAMMOGRAMS RETROSPECTIVE studies TREATMENT effectiveness RISK assessment CANCER patients COMPARATIVE studies DOSE-response relationship (Radiation) DESCRIPTIVE statistics KAPLAN-Meier estimator RADIATION doses RADIOTHERAPY RADIATION injuries DATA analysis software BODY mass index RADIATION dosimetry BREAST tumors EDEMA AXILLARY lymph node dissection CLAVICLE LONGITUDINAL method DISEASE risk factors EVALUATION |
| Zdroj: | Eurasian Journal of Medical Investigation; 2023, Vol. 7 Issue 1, p16-21, 6p |
| Abstrakt: | Objectives: This study aimed to assess the toxicity and cosmetic outcomes in breast cancer patients treated with hypofractionated radiotherapy (HFRT) and identify the risk factors for toxicity. Methods: 56 women with early-stage breast cancer were enrolled in this study. We evaluated physician-rated acute and late RTOG toxicity criteria and cosmetic outcomes during and after RT. Results: The median age was 64. The median follow-up was 90 months. By the end of RT, 29 of 56 (52 %) patients had no acute toxicity according to the RTOG criteria, while 27 (48%) developed grade 1 and grade 2 acute skin toxicity. Twelve patients developed grade 1 edema and skin hyperemia six months after radiotherapy. In contrast, no worse late skin toxicity was observed in 1 year and five-year follow-ups. Multivariate analyses showed that skin toxicity correlated with surgery type (p=0.043), axillary dissection (p=0.032), and supraclavicular radiotherapy (p=0.043). Conclusion: These results verified the viability and safety of HFRT in patients with early breast cancer. Surgery type, axillary surgery type, and supraclavicular radiotherapy were significant adverse prognostic factors for late toxicity. Longterm follow-up is required to confirm this finding. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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