Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation.

Autor: Ferah Okkay, Irmak, Okkay, Ufuk, Bayram, Cemil, Cicek, Betul, Sezen, Selma, Aydin, Ismail Cagri, Mendil, Ali Sefa, Hacimuftuoglu, Ahmet
Předmět:
Zdroj: Drug & Chemical Toxicology; Jan2023, Vol. 46 Issue 1, p69-76, 8p
Abstrakt: The aim of this study was to investigate the molecular, biochemical, and histopathological effects of bromelain, which has antioxidant and anti-inflammatory properties, against cisplatin-induced ocular toxicity. The groups were designed as (1) Control, (2) Cisplatin (7 mg/kg, intraperitoneally), (3) Cisplatin + Bromelain (50 mg/kg, orally for 14 consecutive days), (4) Cisplatin + Bromelain (100 mg/kg, orally for 14 consecutive days). The activity of total antioxidant capacity (TAC) and total oxidant status (TOS) and levels of reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1β (IL-1β), IL-10, nuclear factor kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α) and 8-OHdG were measured in ocular tissue. The mRNA expression of NF-κB and Caspase-3 was also evaluated. Also, ocular sections were evaluated histopathologically. Bromelain demonstrated a dose-dependent protective effect in cisplatin-induced toxicity by regulating oxidative stress, inflammation, and tissue damage. Our results suggested that bromelain may be a potential adjuvant that can protect the eye from cisplatin-induced toxicity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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