| Autor: |
Zhang, Jinhua, Zhao, Mengjia, He, Yufeng, Dong, Yuanzhen |
| Zdroj: |
Journal of Peptide Science; Mar2023, Vol. 29 Issue 3, p1-8, 8p |
| Abstrakt: |
Based on small‐scale synthesis (0.3 g), a 100‐g scale‐up synthesis of crude [Aib8, Arg34]‐glucagon‐like peptide‐1 (GLP‐1) (7–37) was completed. The crude [Aib8, Arg34]‐GLP‐1 (7–37) was purified using a dynamic axial compression column 200 (DAC‐200). Approximately 61 g of [Aib8, Arg34]‐GLP‐1 (7–37) with a purity of >99% was obtained through one‐step reverse‐phase chromatography. The purification yield was approximately 92%. The yield from the total reaction was approximately 60%. In summary, we developed an economical and environmentally friendly route to the synthesis and purification of crude [Aib8, Arg34]‐GLP‐1 (7–37), laying a foundation for subsequent industrial production. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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