| Autor: |
Kanayama, Kazuhiro, Morise, Kimitomo, Nagura, Hiroshi |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Aug1992, Vol. 87 Issue 8, p1018-1022, 5p, 1 Black and White Photograph, 1 Chart, 5 Graphs |
| Abstrakt: |
The distribution and phenotypic characterization of T cell receptor (TCR) γδ cells in human liver tissue was investigated immunohistochemically at fight and electron microscopic levels. In chronic fiver disease, there was a significant increase in the number of TCR γδ cells and in the percentage of TCR γδ cells to CD3+ cells in the portal areas and hepatic sinusoids. Hepatic TCR γδ cells were classified as small or large γδ cells. Large γδ cells were increased in chronic liver disease, whereas both small and large γδ cells were increased in the portal areas and hepatic sinusoids in liver cirrhosis. The increased TCR γδ cells were of the BB3+ (peripheral) type, indicating that TCR γδ cells in the liver were of the same lineage as those in the peripheral blood. In addition, the majority of the TCR γδ cells in the portal areas of liver cirrhosis patients were CD4- and CD8- (double negative). Immunoelectron microscopy showed that the large γδ cells were lymphoblastoid and contained multivesicles. The present study clearly demonstrated that there are two types of TCR γδ cells, and that these cells were significantly increased in the livers of patients with chronic liver disease. This suggests that they may be involved in regulation of the immune response and hepatocellular damage in chronic liver disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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