Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.
| Autor: | Trebach, Joshua, Mahonski, Sarah G., Melchert, Kristina, Howland, Mary Ann, Chiang, William K. |
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| Předmět: |
SPINE abnormalities
ANAL abnormalities ACETYLCYSTEINE IMPERFORATE anus TRACHEAL fistula PHYSICAL diagnosis INTRAVENOUS therapy CO-trimoxazole ACETAMINOPHEN DRUG overdose COLOSTOMY EXTREMITIES (Anatomy) TIME MEDICATION errors POSTOPERATIVE care CONGENITAL heart disease PEDIATRICS TREATMENT effectiveness POISON control centers HUMAN error CONGENITAL disorders OMEPRAZOLE VESICO-ureteral reflux DISCHARGE planning CHILDREN |
| Zdroj: | Journal of Pharmacy Practice; Feb2023, Vol. 36 Issue 1, p173-175, 3p |
| Abstrakt: | The toxicokinetics of pediatric intravenous (IV) acetaminophen (APAP) in overdose is not well described and few case reports with serial APAP concentrations allowing for calculations of half-life exist. Here, we report toxicokinetic data from a case of an unintentional IV APAP overdose in a 12-month-old male who was treated with NAC. Case Report: A 12-month-old (former 24 week gestational age), 8.7 kg male was hospitalized after an uneventful colostomy reversal. In the postoperative unit, the patient unintentionally received 1000 mg IV (114.9 mg/kg) acetaminophen instead of the intended 100 mg IV. Serial acetaminophen concentrations were drawn. The patient received IV Nacetylcysteine and ultimately had no adverse outcomes. Discussion: This case report adds to the existing literature regarding toxicokinetics of IV APAP in infants. Our patient had a calculated ke of 0.263 h-1, correlating with a half-life of 2.63 hours. Based on current available data, the half-life of IV APAP in infants varies (2.6 to 4.9 hours). The reason for this variation is unknown and further research is needed in this area. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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