Autor: |
Galinari, Camila Barros, Biachi, Tiago de Paula, Gonçalves, Renato Sonchini, Cesar, Gabriel Batista, Bergmann, Eduardo Victor, Malacarne, Luis Carlos, Kioshima Cotica, Érika Seki, Bonfim-Mendonça, Patrícia de Souza, Svidzinski, Terezinha Inez Estivalet |
Předmět: |
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Zdroj: |
Critical Reviews in Microbiology; Feb2023, Vol. 49 Issue 1, p38-56, 19p |
Abstrakt: |
Considering the multifaceted and increasing application of photodynamic therapy (PDT), in recent years the antimicrobial employment of this therapy has been highlighted, because of the antiviral, antibacterial, antiparasitic, and antifungal activities that have already been demonstrated. In this context, research focussed on antimycological action, especially for treatment of superficial infections, presents promising growth due to the characteristics of these infections that facilitate PDT application as new therapeutic options are needed in the field of medical mycology. Among the more than one hundred classes of photosensitizers the antifungal action of hypericin (Hyp) stands out due to its ability to permeate the lipid membrane and accumulate in different cytoplasmic organelles of eukaryotic cells. In this review, we aim to provide a complete overview of the origin, physicochemical characteristics, and optimal alternative drug deliveries that promote the photodynamic action of Hyp (Hyp-PDT) against fungi. Furthermore, considering the lack of a methodological consensus, we intend to compile the best strategies to guide researchers in the antifungal application of Hyp-PDT. Overall, this review provides a future perspective of new studies and clinical possibilities for the advances of such a technique in the treatment of mycoses in humans. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
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