| Abstrakt: |
Type 1 abomasal ulcer (AU1) in cattle and buffaloes does not have specific or characteristic clinical signs, and there is a need to identify some early biochemical markers for diagnosis of AU1. The objective of this study was to study the test performance of serum pepsinogen to distinguish healthy buffaloes from the buffaloes with AU1. Blood samples were collected from buffaloes, slaughtered in a buffalo specific slaughter house. Serum was separated for estimation of pepsinogen. After slaughter abomasa were examined for the presence of AU1 and were confirmed by histology. The AU1 were categorized into four subtypes, viz., AU1a, AU1b, AU1c, and AU1d. Buffaloes with AU1 had higher (p < 0.05) mean serum pepsinogen concentration than ulcer negative buffaloes. Among subtypes, AU1b and AU1c had higher (p < 0.05) pepsinogen concentration than other subtypes and ulcer negative buffaloes. The number of ulcers had a positive correlation with the serum pepsinogen concentration, both on overall basis and for each subtype of AU1. As per ROC curve analysis, the optimal value of serum pepsinogen for diagnosis of AU1 was > 3.08 U/L. The values of sensitivity, specificity, positive predictive value, and negative predictive values suggest that serum pepsinogen could be a valid test for the detection of AU1 in buffalo. [ABSTRACT FROM AUTHOR] |
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