| Autor: |
Chen, Rui, Xu, Wan, Sun, Yifu, Zhi, Rongrong, Xie, Peng, Zhi, Zhongwen, Tang, Xiaohong, Zhang, Caiyi |
| Předmět: |
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| Zdroj: |
Neurochemical Research; Feb2023, Vol. 48 Issue 2, p591-603, 13p |
| Abstrakt: |
2-(2-benzofu-ranyl)-2-imidazoline (2-BFI) is a drug that has attracted much attention in recent years. It has a therapeutic effect on brain diseases in animal models such as Alzheimer's disease and cerebral infarction. However, whether 2-BFI affords neuroprotection against the toxicity of fluoride, which can cross the blood–brain barrier and cause neurological dysfunction is not known. We investigated the cell viability and apoptosis of SH-SY5Y cells and primary cultures of cortical neurons exposed to fluoride, and 2-BFI was used to protect both two kinds of cells against the effects of fluoride. We found that 2-BFI can provide neuroprotection on SH-SY5Y cells and primary cultures of cortical neurons upon fluorosis by maintaining the stability of endoplasmic reticulum–mitochondria contact sites and inhibiting activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. This study may provide a new method for protecting against the neurotoxicity induced by fluoride exposure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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