Autor: |
Butenschoen, Vicki M., Schwendner, Maximilian, Hubertus, Vanessa, Onken, Julia, Koegl, Nikolaus, Mohme, Theresa, Maurer, Stefanie, Boeckh-Behrens, Tobias, Eicker, Sven O., Thomé, Claudius, Vajkoczy, Peter, Czabanka, Marcus, Meyer, Bernhard, Wostrack, Maria |
Zdroj: |
Journal of Neuro-Oncology; Jan2023, Vol. 161 Issue 1, p107-115, 9p |
Abstrakt: |
Purpose: Intradural spinal hemangioblastomas are rare highly hypervascularized benign neoplasms. Surgical resection remains the treatment of choice, with a significant risk of postoperative neurological deterioration. Due to the tumor infrequency, scientific evidence is scarce and limited to case reports and small case series. Methods: We performed a retrospective multicenter study including five high-volume neurosurgical centers analyzing patients surgically treated for spinal hemangioblastomas between 2006 and 2021. We assessed clinical status, surgical data, preoperative angiograms, and embolization when available. Follow-up records were analyzed, and logistic regression performed to assess possible risk factors for neurological deterioration. Results: We included 60 patients in Germany and Austria. Preoperative angiography was performed in 30% of the cases; 10% of the patients underwent preoperative embolization. Posterior tumor location and presence of a syrinx favored gross total tumor resection (93.8% vs. 83.3% and 97.1% vs. 84%). Preoperative embolization was not associated with postoperative worsening. The clinical outcome revealed a transient postoperative neurological deterioration in 38.3%, depending on symptom duration and preoperative modified McCormick grading, but patients recovered in most cases until follow-up. Conclusion: Spinal hemangioblastoma patients significantly benefit from early surgical treatment with only transient postoperative deterioration and complete recovery until follow-up. The performance of preoperative angiograms remains subject to center disparities. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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