| Autor: |
Mavadiya, Shashikant, Punatar, Upasana, Vatsaraj, Shreem, Dattani, Pooja, Jain, Shubhangi, Khan, Ayesha aka Arnaz |
| Předmět: |
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| Zdroj: |
International Archives of Integrated Medicine; Jan2023, Vol. 10 Issue 1, p31-34, 4p |
| Abstrakt: |
Multiple Primary Malignant Neoplasms (MPMNs) are rarely reported and are defined as the diagnosis of =2 independent, primary malignancies of different histologies/origins in a single individual. In this study, we report a patient with Male Breast Cancer (MBC) and coexisting Small Lymphocytic Lymphoma (SLL) and Chronic Lymphocytic Leukemia (CLL). A 65-year-old male with complaints of a lump in his left breast since 2 years. CT scan findings were a non-homogeneous mass in the left breast along with bilateral axillary lymphadenopathy. Modified radical mastectomy was done. Microscopic examination showed the features of infiltrating duct carcinoma NOS: Modified Nottingham Bloom Richardson's Grade II in breast specimen. A peripheral smear of the patient showed features of chronic lymphocytic leukemia (absolute lymphocyte count was 16400 cells/mm3). IHC of breast tumor showed ER/PR positivity with H scores of 350 and 240 respectively and HER-2/Neu protein expression was negative with a score of (1+). Lymph nodes were immunoreactive for CD 19, CD 23 and CD 5. Cells were non-reactive for Cyclin D1a and CD3. This is probably the first case of MBC with SLL and CLL. The diagnosis is consistent with synchronous MPMNs, which are increasingly reported nowadays. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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