| Abstrakt: |
배경 Omicron variant virus is spreading rapidly, even in individuals with high vaccination rate. This study aimed to evaluate the effect of vaccine on clinical course of delta and omicron variant infection. Furthermore, we tried to determine the usefulness of antibody titer to spike protein as a predictor of disease course of COVID-19 in vaccinated patients. 방법 Between December 11, 2021 and February 10, 2022, we performed a prospective observational cohort study in an institution of South Korea. Among adult patients admitted due to COVID-19, individuals with confirmed delta and omicron variant infection were included. Multivariable logistic regression anal- ysis was performed to determine the association between antibody titers and clinical course of breakthrough infection in vaccinated patients. The relationship between antibody titers and Ct values was confirmed using a generalized linear model. We used the antibody titers collected within 7 days of symptom onset or diagnosis and Ct values tested on days 5-7 days after initial diagnosis. 결과 Of 161 patients with delta and omicron variant infection, 106 vaccinated patients (39 delta and 67 omi- cron) had available serum samples. The geometric mean titers of antibodies in patients who experienced the fever (≥37.5℃), hypoxia (≤94% of SpO2), pneumonia, CRP elevation (>8 mg/L) or lymphopenia (<1,100 cells/μL) during hospitalization were 1201.5 U/mL, 98.8 U/mL, 774.1 U/mL, 1335.1 U/mL, and 1032.2 U/mL, respectively, which were lower compared with those who did not (P<0.05 for all). Increase in antibody titer of vaccinated patients with delta and omicron infection was associated with decrease in occurrence of fever (aOR, 0.23; 95% CI, 0.12-0.51), hypoxia (aOR, 0.23; 95% CI, 0.08-0.7), CRP elevation (aOR, 0.52; 95% CI, 0.29-0.0.94), and lymphopenia (aOR, 0.57; 95% CI, 0.33-0.98) during hospitalization, regardless of virus type or booster vaccination status. Data from 33 patients who had suitable Ct values showed a positive correlation between antibody levels and Ct values (P=0.02). 결론 Antibody titer is predictive of clinical course of COVID-19 in vaccinated patients with delta and omi- cron variant infection. Our data highlight the need for concentrated efforts to monitor patients with SARS-CoV-2 infection who have a risk for low antibody titers. [ABSTRACT FROM AUTHOR] |
