| Autor: |
Banai, Ariel, Lupu, Lior, Shetrit, Aviel, Hochstadt, Aviram, Lichter, Yael, Levi, Erez, Szekely, Yishay, Schellekes, Nadav, Jacoby, Tammy, Zahler, David, Itach, Tamar, Taieb, Philippe, Gefen, Sheizaf, Viskin, Dana, Shidlansik, Lia, Adler, Amos, Levitsky, Ekaterina, Havakuk, Ofer, Banai, Shmuel, Ghantous, Eihab |
| Předmět: |
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| Zdroj: |
European Heart Journal - Cardiovascular Imaging; Jan2023, Vol. 24 Issue 1, p59-67, 9p |
| Abstrakt: |
Aims Preliminary data suggested that patients with Omicron-type-Coronavirus-disease-2019 (COVID-19) have less severe lung disease compared with the wild-type-variant. We aimed to compare lung ultrasound (LUS) parameters in Omicron vs. wild-type COVID-19 and evaluate their prognostic implications. Methods and results One hundred and sixty-two consecutive patients with Omicron-type-COVID-19 underwent LUS within 48 h of admission and were compared with propensity-matched wild-type patients (148 pairs). In the Omicron patients median, first and third quartiles of the LUS-score was 5 [2–12], and only 9% had normal LUS. The majority had either mild (≤5; 37%) or moderate (6–15; 39%), and 15% (≥15) had severe LUS-score. Thirty-six percent of patients had patchy pleural thickening (PPT). Factors associated with LUS-score in the Omicron patients included ischaemic-heart-disease, heart failure, renal-dysfunction, and C-reactive protein. Elevated left-filling pressure or right-sided pressures were associated with the LUS-score. Lung ultrasound-score was associated with mortality [odds ratio (OR): 1.09, 95% confidence interval (CI): 1.01–1.18; P = 0.03] and with the combined endpoint of mortality and respiratory failure (OR: 1.14, 95% CI: 1.07–1.22; P < 0.0001). Patients with the wild-type variant had worse LUS characteristics than the matched Omicron-type patients (PPT: 90 vs. 34%; P < 0.0001 and LUS-score: 8 [5, 12] vs. 5 [2, 10], P = 0.004), irrespective of disease severity. When matched only to the 31 non-vaccinated Omicron patients, these differences were attenuated. Conclusion Lung ultrasound-score is abnormal in the majority of hospitalized Omicron-type patients. Patchy pleural thickening is less common than in matched wild-type patients, but the difference is diminished in the non-vaccinated Omicron patients. Nevertheless, even in this milder form of the disease, the LUS-score is associated with poor in-hospital outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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