Mortality in cancer patients with SARS-CoV-2 or seasonal influenza: an observational cohort study from a German-wide hospital network.

Autor:	Kodde, Cathrin, Bonsignore, Marzia, Schöndube, Daniel, Bauer, Torsten, Hohenstein, Sven, Bollmann, Andreas, Meier-Hellmann, Andreas, Kuhlen, Ralf, Nachtigall, Irit
Předmět:	INTENSIVE care units COVID-19 SCIENTIFIC observation IMMUNIZATION AGE distribution COVID-19 vaccines PATIENTS METASTASIS CANCER patients ARTIFICIAL respiration HOSPITAL mortality HOSPITAL admission & discharge SEX distribution SEASONAL influenza DESCRIPTIVE statistics ODDS ratio
Zdroj:	Infection; Feb2023, Vol. 51 Issue 1, p119-127, 9p, 5 Charts, 1 Graph
Abstrakt:	Purpose: At the beginning of the COVID-19 pandemic, SARS-CoV-2 was often compared to seasonal influenza. We aimed to compare the outcome of hospitalized patients with cancer infected by SARS-CoV-2 or seasonal influenza including intensive care unit admission, mechanical ventilation and in-hospital mortality. Methods: We analyzed claims data of patients with a lab-confirmed SARS-CoV-2 or seasonal influenza infection admitted to one of 85 hospitals of a German-wide hospital network between January 2016 and August 2021. Results: 29,284 patients with COVID-19 and 7442 patients with seasonal influenza were included. Of these, 360 patients with seasonal influenza and 1625 patients with COVID-19 had any kind of cancer. Cancer patients with COVID-19 were more likely to be admitted to the intensive care unit than cancer patients with seasonal influenza (29.4% vs 24.7%; OR 1.31, 95% CI 1.00–1.73 p <.05). No statistical significance was observed in the mechanical ventilation rate for cancer patients with COVID-19 compared to those with seasonal influenza (17.2% vs 13.6% OR 1.34, 95% CI 0.96–1.86 p =.09). 34.9% of cancer patients with COVID-19 and 17.9% with seasonal influenza died (OR 2.45, 95% CI 1.81–3.32 p <.01). Risk factors among cancer patients with COVID-19 or seasonal influenza for in-hospital mortality included the male gender, age, a higher Elixhauser comorbidity index and metastatic cancer. Conclusion: Among cancer patients, SARS-CoV-2 was associated with a higher risk for in-hospital mortality than seasonal influenza. These findings underline the need of protective measurements to prevent an infection with either COVID-19 or seasonal influenza, especially in this high-risk population. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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