| Autor: |
Thanh, Nguyen Dinh, Hai, Do Son, Huyen, Le Thi, Thuy, Vu Thi Tuyet, Tung, Do Tien, Van, Hoang Thi Kim, Toan, Vu Ngoc, Giang, Nguyen Thi Kim, Tri, Nguyen Minh |
| Předmět: |
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| Zdroj: |
Research on Chemical Intermediates; Feb2023, Vol. 49 Issue 2, p525-555, 31p |
| Abstrakt: |
In this work, we prepared successfully a recoverable heterogeneous magnetic nano-catalyst Fe3O4-MNPs@MMT-K10. This catalyst was characterized by energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy techniques. Its catalytic behavior was efficiently used for the synthesis of highly substituted pyran/chromene derivatives (4a–m and 6a–m, respectively) containing propargyl unit through a one-pot three-component condensation of propargyl acetoacetate/3-propargyloxyphenol, malononitrile, and arylaldehydes under microwave-assisted solvent-free conditions. Some important features of this catalyst were found, including short reaction times, excellent yields, lower loading of the catalyst, easy work-up, and recyclability. It was showed that the obtained catalyst exhibited the catalytic stability and the reusability for a minimum of six times without any noticeable decrease in its catalytic activity. Also, thirteen novel substituted propargyl 6-amino-4-aryl-5-cyano-2-methyl-4H-pyran-3-carboxylates 4a–m were synthesized by three-component reaction of propargyl acetoacetate with malononitrile and benzaldehydes using this catalyst. Their structure was determined by measuring the spectral properties as well as by single-crystal X-ray crystallography of a representative compound 4i. 1-Alkyne was one of the two substances needed for click chemistry, along with organic azides and propargyl esters as well as ethers were synthesized for this purpose. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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