Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats.
| Autor: | Jiang, Nengmei, Zhang, Yuanyuan |
|---|---|
| Předmět: |
GLUCOSE metabolism
DRUG efficacy GLYCOSYLATED hemoglobin ALKALINE phosphatase BODY weight CARBOHYDRATE metabolism ANIMAL experimentation GLYCEMIC control CELL receptors HYPOGLYCEMIC agents AMINOGLYCOSIDES TYPE 2 diabetes HYDROCARBONS RATS INSULIN OXIDATIVE stress DIETARY fats CARRIER proteins ALANINE aminotransferase ASPARTATE aminotransferase |
| Zdroj: | Human & Experimental Toxicology; Jan-Dec2022, Vol. 41, p1-13, 13p |
| Abstrakt: | The present study was designed to investigate the antidiabetic effect of nerolidol on high-fat diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in animals by feeding them a high-fat diet for 4 weeks and administering a single intraperitoneal dose of streptozotocin (35 mg/kg body weight). Diabetic rats were treated with nerolidol (25 mg/kg BW) for 28 days. Results showed that nerolidol treatment significantly reduced (p < 0.05) the level of elevated glucose, glycosylated hemoglobin and improved (p < 0.05) the body weight and insulin level. Nerolidol also considerably improved (p < 0.05) the carbohydrate metabolic enzyme activities and increased the glycogen storage in the liver of diabetic rats. Increased serum triglycerides, total cholesterol (C), low-density lipoproteins-C and very low-density lipoproteins-C levels were significantly lowered (p < 0.05), while reduction of serum high-density lipoprotein-C was alleviated after administration of nerolidol. In addition, nerolidol attenuated oxidative stress markers by significantly increasing (p < 0.05) the levels of superoxide dismutase, catalase, reduced glutathione, and lowering (p < 0.05) the level of thiobarbituric acid reactive substances, and lipid hydroperoxide. Similarly, nerolidol showed its pharmacological effects against hepatic markers via restoring (p < 0.05) the alleviated level of alanine transaminase, aspartate aminotransferase, and alkaline phosphatase. Finally, it improved insulin-dependent glucose transport in skeletal muscle by enhancing and activating glucose transporter protein-4. These findings confirmed the antidiabetic potential of nerolidol in type 2 diabetic rats. This may be related to a high antioxidant capacity, the restoration of plasma insulin and lipid levels, and the activation of insulin signaling in STZ/HFD-induced diabetic rats. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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