| Autor: |
Newton, Josiah J., Engüdar, Gökçe, Brooke, Alan J., Nodwell, Matthew B., Horngren‐Rhodes, Holly, Martin, Rainer E., Schaffer, Paul, Britton, Robert, Friesen, Chadron M. |
| Předmět: |
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| Zdroj: |
Chemistry - A European Journal; 1/24/2023, Vol. 29 Issue 5, p1-5, 5p |
| Abstrakt: |
The difluoromethyl group plays an important role in modern medicinal and agrochemistry. While several difluoromethylation reagents have been reported, these typically rely on difluoromethyl carbenes or anions, or target specific processes. Here, we describe a conceptually unique and general process for O−H, N−H and C−H difluoromethylation that involves the formation of a transient dithiole followed by facile desulfurative fluorination using silver(I) fluoride. We also introduce the 5,6‐dimethoxy‐1,3‐benzodithiole (DMBDT) function, which undergoes sufficiently rapid desulfurative fluorination to additionally support 18F‐difluoromethylation. This new process is compatible with the wide range of functional groups typically encountered in medicinal chemistry campaigns, and the use of Ag18F is demonstrated in the production of 18F‐labeled derivatives of testosterone, perphenazine, and melatonin, 58.0±2.2, 20.4±0.3 and 32.2±3.6 MBq μmol−1, respectively. We expect that the DMBDT group and this 18F/19F‐difluoromethylation process will inspire and support new efforts in medicinal chemistry, agrochemistry and radiotracer production. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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