| Autor: |
Singh, Atamjit, Kaur, Harpreet, Singh, Hasandeep, Singh, Balbir, Bedi, Preet Mohinder Singh, Kaur, Sarabjit |
| Zdroj: |
Journal of Herbs, Spices & Medicinal Plants; 2023, Vol. 29 Issue 1, p63-72, 10p |
| Abstrakt: |
The analgesic and anti-inflammatory effects of Grewia asiatica leaf solvent extracts were evaluated in animal models. The methanol and ethyl acetate fractions prepared from the leaves showed potent analgesic and anti-inflammatory effects at 400 mg kg−1 and 100 mg kg−1, respectively. Myricetin was isolated from the ethyl acetate fraction by column chromatography. Molecular docking studies with myricetin showed a desirable binding pattern of myricetin with both COX-1 and COX-2, supporting its anti-inflammatory potential. Results showed that the anti-inflammatory and analgesic effect of methanol extract of G. asiatica leaves may be due to COX-1 and COX-2 inhibition by myricetin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
