| Autor: |
Sedaghat, Alireza, Ahmadabadi, Ali, Tavousi, Seyed Hassan, Fazli, Benyamin, Khorsand, Mahmood, Feyzabadi, Bita Mirzaie |
| Předmět: |
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| Zdroj: |
Reviews in Clinical Medicine; Jun2022, Vol. 9 Issue 2, p59-64, 6p |
| Abstrakt: |
Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but potentially life-threatening reactions to medications. Both conditions have significant morbidity and mortality. This study aimed to document the epidemiological features, aetiologies, treatment and clinical outcomes of such patients. Methods: In this retrospective cross-sectional study the records of all patients with TEN treated for5 years in central Hospital, Mashhad, Iran were reviewed. Results: Thirty-four patients were studied with a mean age of 26.5 years. Mean age in the mortality and survivors groups was 33.6 and 25.3 years, respectively. Drugs accounted for all 34 cases were including Anti-convulsants (%52.9) other the most common implicated drug followed by antibiotics (%26.5), allopurinol (%5.9) and multiple drugs (anticonvulsants plus antibiotics) (%14.7). Antibiotics had the shortest interval between ingestion time and onset of symptoms. The mean ICU length of stay was 12.7 days, with a range of 1 to 30 days. The mean of SCORTEN was 2.3; it was 3.3 and 2.1 in the mortality and survivors group, respectively (P=0.001). All 34 TEN cases were given intravenous immunoglobulins (IVIG). Six patients with TEN died (%17.6). The highest mortality was found in the allopurinol group with %50, whereas anticonvulsants and antibiotics had a mortality rate of %16.6 and %15.3, respectively. Conclusion: Anti-convulsants especially Lamotrigine were the most frequently implicated drug, followed by antibiotics and allopurinol. IVIG was shown beneficial effects in TEN syndrome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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