| Autor: |
Cunha Cardoso, Viviane, Grandi, Carlos, Silveira, Rita C., Bandeira Duarte, José Luiz, Ferrarez Bouzada Viana, Maria Cândida, Marques de Lima Mota Ferreira, Daniela, Sales Alves Junior, José Mariano, Furlan Embrizi, Laís, Boschi Gimenes, Carolina, Moura de Mello e Silva, Nathalia, Pegoraro de Godoi Melo, Fernanda, Stadler Venzon, Paulyne, Barcala Gomez, Dafne, Silva do Vale, Marynéa, Regina Bentlin, Maria, Carvalho de Moraes Barros, Marina, Monteiro Bigélli Cardoso, Laura Emilia, Maria de Albuquerque Diniz, Edna, Hecker Luz, Jorge, Martins Marba, Sérgio Tadeu |
| Předmět: |
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| Zdroj: |
Jornal de Pediatria; Jan/Feb2023, Vol. 99 Issue 1, p86-93, 8p |
| Abstrakt: |
Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Method: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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