| Autor: |
Sukardi, Sukardi, Damat, Damat, Mousa Atoum, Manar Fayiz, Zalizar, Lili, Relawati, Rahayu, Jan, Asad, Vincēviča-Gaile, Zane, Andoko, Effendi, Warkoyo, Warkoyo |
| Předmět: |
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| Zdroj: |
Jordan Journal of Biological Sciences; Dec2022, Vol. 15 Issue 5, p897-904, 8p |
| Abstrakt: |
Diabetes (DMT 2) is one of the most common free radicals-incited conditions, and its treatment calls for natural antioxidants fit for daily administration with minimum burden to the bodily system. Traditionally used to treat eye disease in Indonesia, kitolod [Isotoma longiflora (L) Presl.] was studied for its antidiabetic prospect. Hexane extracts from the leaves and fruit were analyzed for their non-polar chemical compounds, antioxidant properties, and α-amylase and α-glucosidase enzyme inhibition activities. Liquid chromatography (LC)-mass spectrometry (MS) identified 29 compounds out of the leaf and 36 compounds out of the fruit. The extracts showed moderate antioxidant activity with IC50 values of (90.586 ± 0.663) μg mL–1 and (92.832 ± 1.042) μg mL–1. Their inhibitory against α-amylase was very strong, with IC50 values of (38.511 ± 0.068) mL–1 and (39.790 ± 0.233) mL–1, while ones against α-glucosidase were strong to moderate with IC50 value of leaf extract (40.833 ± 0.571) μg mL–1 and of fruit extract (65.383 ± 0.511) μg mL–1. Seeing the high potential in kitolod extracts to inhibit α-amylase and α-glucosidase enzymes, they should correspond with functional food for people with diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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