| Autor: |
Pallam, Goldamol S., Sam, Sonia, S., Swathy, Kumar, K. Girish |
| Zdroj: |
Ionics; Feb2023, Vol. 29 Issue 2, p819-831, 13p |
| Abstrakt: |
Monoamine neuromodulators norepinephrine (NE) and octopamine (OA) have been discovered to coexist and are associated with neurological and cardiovascular pathology. Here, we have developed a voltammetric sensor to determine NE and OA individually as well as simultaneously using an eco-friendly and cost-effective amino acid modifier, tyrosine (Tyr), which possesses favourable adsorption sites for the binding of these analytes. At poly-Tyr modified glassy carbon electrode (p-Tyr/GCE), the neuromodulators exhibited increased current response at lower overpotential than at the bare GCE. The submicromolar determination of these neuromodulators on p-Tyr/GCE was demonstrated in linear dynamic ranges (LDR) over 7.00 × 10−6–1.00 × 10−6 M and 9.00 × 10−7–1.00 × 10−7 M for NE and over the ranges 1.00 × 10−5–2.00 × 10−6 M and 1.00 × 10−6–2.00 × 10−7 M for OA with the detection limits of 1.37 × 10−8 M and 4.74 × 10−8 M for NE and OA, respectively. The mechanistic aspects were studied and the electro-oxidation of NE and OA on p-Tyr/GCE was found to be two electrons, two-proton transfer reaction. The utility of the proposed method was validated by the determination of NE in pharmaceutical formulations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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