| Autor: |
Nayci, Ali, Cakmak, Murat, Renda, Nurten, Aksoyek, Selim, Yucesan, Selcuk |
| Předmět: |
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| Zdroj: |
International Journal of Colorectal Disease; Mar2003, Vol. 18 Issue 2, p136-141, 6p, 2 Graphs |
| Abstrakt: |
Background and aims. Studies have indicated a deleterious effect of perioperative 5-fluorouracil (5-FU) administration on the healing of intestinal anastomoses. This study examined the effect of early postoperative 5-FU on the healing of colonic anastomoses and investigated the effect of electromagnetic fields (EMF) on colonic anastomotic repair under normal physiological conditions and in the presence of 5-FU therapy in a rat model. Materials and methods. Forty male Wistar rats were randomly assigned into four groups and underwent a standardized left colonic resection and anastomoses. The animals then served as control or received intraperitoneal 5-FU (20 mg/kg per day, 5 days), EMF stimulation (10.76 mT, 50 Hz; 2-h on/10-h off cycles, 7 days) or both, starting on the day of surgery. After 7 days anastomotic healing was assessed by measurement of hydroxyproline content and breaking strength. Results. Hydroxyproline content increased in EMF exposed group (1.53±0.11 to 1.92±0.11 µg/mg) and in EMF + 5-FU group (1.53±0.11 to 1.89±0.12 µg/mg). Breaking strength also increased in the EMF group (0.23±0.02 to 0.27±0.01 MPa) and in the EMF + 5-FU group (0.23±0.02 to 0.28±0.01 MPa. No differences were found in hydroxyproline content or breaking strength between the 5-FU group and controls. Conclusion. Early postoperative 5-FU administration did not impair the healing of colonic anastomoses in rats. Additionally, EMF stimulation provided a significant gain in colonic anastomotic strength, in rat intestines in control animals and in animals exposed to 5-FU. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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