| Autor: |
Thier, Ricarda, Lewalter, Jürgen, Selinski, Silvia, Bolt, Hermann M. |
| Předmět: |
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| Zdroj: |
International Archives of Occupational & Environmental Health; Sep2001, Vol. 74 Issue 7, p483-488, 6p |
| Abstrakt: |
The high priority of monitoring workers exposed to nitrobenzene is a consequence of clear findings of experimental carcinogenicity of nitrobenzene and the associated evaluations by the International Agency for Research on Cancer. Eighty male employees of a nitrobenzene reduction plant, with potential skin contact with nitrobenzene and aniline, participated in a current medical surveillance programme. Blood samples were routinely taken and analysed for aniline, 4-aminodiphenyl (4-ADP) and benzidine adducts of haemoglobin (Hb) and human serum albumin (HSA). Also, levels of methaemoglobin (Met-Hb) and of carbon monoxide haemoglobin (CO-Hb) were monitored. Effects of smoking were straightforward. Using the rank sum test of Wilcoxon, we found that very clear-cut and statistically significant smoking effects (about 3-fold increases) were apparent on CO-Hb (P=0.00085) and on the Hb adduct of 4-ADP (P=0.0006). The mean aniline-Hb adduct level in smokers was 1.5 times higher than in non-smokers; the significance (P=0.05375) was close to the 5% level. The strongest correlation was evident between the Hb and HSA adducts of aniline (rs=0.846). Less pronounced correlations (but with P values < 0.02) appeared between aniline-Hb and 4-ADP-Hb adducts (rs=0.388), between 4-ADP and 4-ADP-HSA adducts (rs=0.373), and between 4-ADP-Hb and aniline-HSA adducts (rs=0.275). In view of the proposal for additional use of the aniline-HSA adduct for biological monitoring, particularly in cases of acute overexposures or poisonings, the strong correlation of the Hb and HSA conjugates is noteworthy; the ratio aniline-HSA:aniline-Hb was 1:42 for the entire cohort. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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