| Autor: |
Brorson, M., Hougaard, D. M, Nielsen, J. H, Tornehave, D., Larsson, L.-I. |
| Předmět: |
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| Zdroj: |
Histochemistry & Cell Biology; Sep2001, Vol. 116 Issue 3, p263-267, 5p |
| Abstrakt: |
Members of the TGF-β superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-β members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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