| Autor: |
Cambou, Mary C, Liu, Christine M, Mok, Thalia, Fajardo-Martinez, Viviana, Paiola, Sophia G, Ibarrondo, Francisco J, Kerin, Tara, Fuller, Trevon, Tobin, Nicole H, Garcia, Gustavo, Bhattacharya, Debika, Aldrovandi, Grace M, Arumugaswami, Vaithilingaraja, Foo, Suan-Sin, Jung, Jae U, Vasconcelos, Zilton, Brasil, Patricia, Brendolin, Michelle, Yang, Otto O, Rao, Rashmi |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/15/2023, Vol. 227 Issue 2, p236-245, 10p |
| Abstrakt: |
Background: There are limited data on how COVID-19 severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies.Methods: In a longitudinal cohort of pregnant women with PCR-confirmed SARS-CoV-2 infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike IgG, IgM and IgA were measured by ELISA.Results: 256 pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least one isotype. Symptomatic disease, and vaccination prior to delivery, were associated with higher maternal IgG at L&D. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (OR 4.0), mild/moderate disease (OR 4.8), severe/critical disease (OR 6.3), and maternal vaccination prior to delivery (OR 18.8). No factors were significant in the multivariate analysis at 6 months postpartum.Conclusions: Vaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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