| Autor: |
Bialasiewicz, Seweryn, May, Meryta, Tozer, Sarah, Day, Rebecca, Bernard, Anne, Zaugg, Julian, Gartrell, Kyana, Alexandersen, Soren, Chamings, Anthony, Wang, Claire Y T, Clark, Julia, Grimwood, Keith, Heney, Claire, Schlapbach, Luregn J, Ware, Robert S, Speers, David, Andrews, Ross M, Lambert, Stephen |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/15/2023, Vol. 227 Issue 2, p278-287, 10p |
| Abstrakt: |
Background A novel human parechovirus 3 Australian recombinant (HPeV3-AR) strain emerged in 2013 and coincided with biennial outbreaks of sepsis-like illnesses in infants. We evaluated the molecular evolution of the HPeV3-AR strain and its association with severe HPeV infections. Methods HPeV3-positive samples collected from hospitalized infants aged 5–252 days in 2 Australian states (2013–2020) and from a community-based birth cohort (2010–2014) were sequenced. Coding regions were used to conduct phylogenetic and evolutionary analyses. A recombinant-specific polymerase chain reaction was designed and utilized to screen all clinical and community HPeV3-positive samples. Results Complete coding regions of 54 cases were obtained, which showed the HPeV3-AR strain progressively evolving, particularly in the 3′ end of the nonstructural genes. The HPeV3-AR strain was not detected in the community birth cohort until the initial outbreak in late 2013. High-throughput screening showed that most (>75%) hospitalized HPeV3 cases involved the AR strain in the first 3 clinical outbreaks, with declining prevalence in the 2019–2020 season. The AR strain was not statistically associated with increased clinical severity among hospitalized infants. Conclusions HPeV3-AR was the dominant strain during the study period. Increased hospital admissions may have been from a temporary fitness advantage and/or increased virulence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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