Marked (24-fold) elevation of peritoneal cavity drainage fluid vascular endothelial growth factor after successful "patch, drain, and wait" approach for extensive midgut necrosis in a newborn.

Autor:	Moore, Thomas C., Collins, David L., Nguyen, Mai
Předmět:	VASCULAR endothelial growth factors ISCHEMIA NECROSIS CYTOKINES NEOVASCULARIZATION CEREBRAL anoxia ACUTE abdomen
Zdroj:	Pediatric Surgery International; Jul2002, Vol. 18 Issue 5/6, p400-404, 5p
Abstrakt:	In a current publications, it has been suggested that hypoxia-triggered "good angiogenesis" involving hypoxic up-regulation of vascular endothelial growth factor (VEGF) molecules, genes, and receptors is likely responsible in a major way for the remarkable gut and patient salvage experience associated with use of the "patch, drain, and wait" (PD&W) surgical approach to perforated necrotizing enterocolitis and midgut volvulus (MGV) with extensive ischemia/necrosis. We report a case in which extensive ischemia/necrosis in a newborn with gastroschisis (likely MGV-induced) was managed successfully by PD&W with an associated marked (24-fold) elevation of VEGF in drainage fluid at 7 days post-initiation of PD&W. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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