| Autor: |
Kusumastuti, Etty Hary, Wiratama, Priangga Adi, Ariani, Grace, Djuanda, Stephanie Natasha, Rahniayu, Alphania, Kurniasari, Nila, Fauziah, Dyah, Rahaju, Anny Setijo, Marhana, Isnin Anang, Rosyid, Alfian Nur, Wahyu, Dwi, Nugroho, Gilang Muhammad Setyo, Anggoro, Adhitri, Yandi, I. Komang Rusgi, Semedi, Bambang Pujo, Lilihata, Jilientasia Godrace, Maimunah, Ummi, Supriadi, Lefi, Achmad, Rinjani, Lalu Galih Pratama |
| Předmět: |
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| Zdroj: |
Pharmacognosy Journal; 2022 Supplement, Vol. 14, p887-892, 6p |
| Abstrakt: |
Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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