Glucose variability increases during minimally invasive procedures in very preterm infants.

Autor: Galderisi, Alfonso, Res, Giulia, Guiducci, Silvia, Savio, Federica, Brigadoi, Sabrina, Forlani, Laura, Mastrandrea, Biancamaria, Moschino, Laura, Lolli, Elisabetta, Priante, Elena, Trevisanuto, Daniele, Baraldi, Eugenio
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Zdroj: European Journal of Pediatrics; Jan2023, Vol. 182 Issue 1, p89-94, 6p, 1 Diagram, 1 Chart, 2 Graphs
Abstrakt: The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (≤ 32 weeks gestation and/or birthweight ≤ 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV = SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29–31]; birthweight 1300 g [950–1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p = 0.010 and 0.030), and nappy change (p < 0.001 and < 0.001), in the absence of a difference during parental presence. Conclusions: Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose. What is Known: • Minimally invasive procedures - including nappy change - may increase neonatal stress in preterm infants. What is New: • Continuous glucose monitoring provides a quantitative measure of neonatal stress during neonatal care procedures demonstrating an increase of glucose variability. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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