High dose melphalan is an adequate preparative regimen for autologous hematopoietic stem cell transplantation in relapsed/refractory lymphoma.

Autor: Fernández-Gutiérrez, José A., Reyes-Cisneros, Oscar A., Litzow, Mark R., Bojalil-Álvarez, Lorena, García-Villaseñor, Elizabeth, Gómez-Gomez, Eliezer Tomas, Murrieta-Álvarez, Iván, Gomez-Almaguer, David, Gutierrez-Aguirre, Cesar H., Karduss-Urueta, Amado J., Ruiz-Delgado, Guillermo J., Ruiz-Argüelles, Guillermo José
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Zdroj: Hematology; Dec2022, Vol. 27 Issue 1, p449-455, 7p
Abstrakt: High-dose melphalan (HD-Mel) has been successfully employed in autografting patients with multiple myeloma. An advantage of this regimen is that the total dose of Mel can be delivered in a single day, being particularly useful when non-frozen hematopoietic stem cells are employed in the autograft. All consecutive patients with R/R lymphomas, both HL and NHL studied and treated at two different centers were prospectively included in a study of ASCT employing a single dose of HD-Mel (200 mg/m2). A group of R/R HL or NHL autografted employing BEAM-like preparative regimens was constructed matched by diagnosis and age. The primary endpoint of the study was overall survival (OS), the secondary endpoint was event-free survival (EFS). Twenty-five R/R HL/NHL patients were prospectively accrued in the study. There were 8 (32%) females, 13 (52%) patients had at least 1 adverse effect: 7 (28%) developed mucositis, 5 (20%) neutropenic fever, and 6 (24%) grade IV nausea. In the HD-Mel group, median overall survival (OS) was not achieved and OS at 36 months was 71%, the transplant-related mortality being 0%. In the control group, median OS was not achieved and the 36-month OS was 76%, results not statistically significant (p 0.5). The EFS was also similar in both groups (p 0.5). HD-Mel alone is non-inferior to a BEAM-like regimen as a preparative regimen for autografting patients with R/R HL and NHL. The regimen is adequate to graft persons with non-frozen stem cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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