Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-γ and IL-4 expression in psoriatic skin in situ.

Autor:	Piskin, Gamze, Heydendael, Vera M. R., de Rie, Menno A., Bos, Jan D., Teunissen, Marcel B. M.
Předmět:	CYCLOSPORINE METHOTREXATE THERAPEUTICS T cells SKIN injuries PSORIASIS
Zdroj:	Archives of Dermatological Research; Dec2002, Vol. 294 Issue 12, p559-562, 4p
Abstrakt:	Examines the effectiveness of cyclosporin A and methotrexate in reducing T cell numbers in psoriatic skin lesions. Involvement of T cells in the pathogenesis of psoriasis; Contribution of high interferon expression in the inflammation of psoriatic skin via its proinflammatory effects; Detection of the ability of cyclosporin A to inhibit T cell activation via inhibition of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells.
Databáze:	Complementary Index
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