n -3 PUFA can reduce IL-6 and TNF levels in patients with cancer.
| Autor: | Guo, Yongzhong, Ma, Bo, Li, Xinhua, Hui, Hui, Zhou, Yun, Li, Na, Xie, Xiaomei |
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| Předmět: |
THERAPEUTIC use of omega-3 fatty acids
INTERLEUKINS CYTOKINES ONLINE information services PUBLICATION bias META-analysis MEDICAL information storage & retrieval systems CONFIDENCE intervals SYSTEMATIC reviews REGRESSION analysis CANCER patients OMEGA-3 fatty acids TUMOR necrosis factors TUMORS MEDLINE DATA analysis software CHEMICAL inhibitors |
| Zdroj: | British Journal of Nutrition; 1/14/2023, Vol. 129 Issue 1, p54-65, 12p |
| Abstrakt: | Current studies on inhibitory effects of n -3 PUFA on pro-inflammatory cytokines have inconsistent results. Thus, a meta-analysis of randomised controlled trials was conducted to identify the effects of n -3 PUFA administration on circulating IL-6 and TNF in patients with cancer. Studies that examined the effects of n -3 PUFA administration on circulating IL-6 and TNF in patients with cancer were identified by searching PubMed and EMBASE from January 1975 to February 2021. Differences in n -3 PUFA administration and control conditions were determined by calculating standardised mean differences (SMD) with 95 % CI. Twenty studies involving 971 patients met the inclusion criteria. The overall SMD were 0·485 (95 % CI 0·087, 0·883) for IL-6 and 0·712 (95 % CI 0·461, 0·962) for TNF between n -3 PUFA administration and control conditions. Sources of heterogeneity were not found through subgroup and meta-regression analyses. Publication bias was observed in TNF with a slight contribution to the effect size. n -3 PUFA can reduce circulating IL-6 and TNF levels in patients with cancer. Results supported the recommendation of n -3 PUFA as adjuvant therapy for patients with cancer, possibly excluding head and neck cancer, owing to their anti-inflammatory properties. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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