| Autor: |
Winchester, Elizabeth C., Millwood, Iona Y., Rand, Lucinda, Penny, Michelle A., Kessling, Anna M. |
| Předmět: |
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| Zdroj: |
Human Genetics; Dec2000, Vol. 107 Issue 6, p591-596, 6p |
| Abstrakt: |
Asthma is a complex disease involving genetic and environmental aetiology. The tumour necrosis factor-alpha (TNF-α) and angiotensin-converting enzyme (ACE) genes have been implicated in asthma pathogenesis. This study investigated the association of a G-308A variant of TNF-α and an insertion/deletion (I/D) variant of ACE with a self-reported history of childhood asthma, in two population groups. At Northwick Park Hospital, London, 1,811 pregnant women attending for antenatal care were recruited. Participants with a self-reported history of childhood asthma, determined by a researcher-administered questionnaire, and controls with no personal or family history of asthma, of UK/Irish (cases n=20; controls n=416) and South Asian (cases n=6; controls n=275) origin were used in this study. Participants were genotyped for the TNF-α-308 and ACE I/D variants by a PCR-RFLP and PCR approach. The TNF-α-308 allele 2 (-308A) was significantly associated with self-reported childhood asthma in the UK/Irish (Odds ratios (OR): 2.6; 95% confidence intervals (CI): 1.1–6.2; P=0.03) but not in the South Asian population. The ACE DD genotype was not associated with childhood asthma in either population group. Gametic phase disequilibrium between the TNF-α-308 and ACE I/D variants was significantly different from zero in UK/Irish cases (Δ=0.09; P=0.034). The TNF-α-308 allele 2 or a linked major histocompatibility complex (MHC) variant may be a genetic risk factor for childhood asthma in the UK/Irish sample. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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