| Autor: |
Waluyo, Danang, Siska, Eka, Chrisnayanti, Evita, Pramisandi, Amila, Dewi, Diana, Puspitasari, Dian Japany, Dobashi, Kazuyuki, Mori, Mihoko, Oktaviani, Avi Nurul, Hidayati, Dyah Noor, Prabandari, Erwahyuni Endang, Nugroho, Nuki Bambang, Shiomi, Kazuro, Nozaki, Tomoyoshi, Harmoko, Rikno, Nuryana, Isa, Izzati, Fauzia Nurul, Sarwono, Ki Ageng, Khaerunnisa, Isyana, Rahmawati, Siti Irma |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 12/23/2022, Vol. 2606 Issue 1, p1-7, 7p |
| Abstrakt: |
An Indonesia soil actinomycete, Streptomyces sp. BioMCC-a.T.3335 was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum cell proliferation. The properties of active compounds in the extract were examined by conducting a preliminary extraction test (PET). Extraction and purification method of active compounds was developed based on PET result. We identified two active compounds, cosmomycin A (1) and B (2), from the extract as active compounds. Cosmomycin A inhibited the proliferation of P. falciparum 3D7 cell in vitro (IC50=2.8 nM). To our best knowledge, 1 and 2 have never been reported as anti-malarial agents before. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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