Room‐Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System.

Autor:	Shet, Harshita, Patel, Manisha, Waikar, Jyoti M., More, Pavan M., Sanghvi, Yogesh S., Kapdi, Anant R.
Předmět:	PUROMYCIN PURINES DIMETHYLAMINE HETEROARENES
Zdroj:	Chemistry - An Asian Journal; 1/3/2023, Vol. 18 Issue 1, p1-7, 7p
Abstrakt:	The dimethylamino functionality has significant importance in industrially relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room‐temperature dimethylamination of chloroheteroarenes performed via the in‐situ generation of dimethylamine using N,N‐dimethylformamide (DMF) as precursor wiith a large substrate scope that includes various heteroarenes, purines as well as commercially relevant drugs such as altretamine, ampyzine and puromycin precursor. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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