| Autor: |
Lowe, Phillip T., O'Hagan, David |
| Předmět: |
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| Zdroj: |
Chemical Society Reviews; 1/7/2023, Vol. 52 Issue 1, p248-276, 29p |
| Abstrakt: |
The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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