| Autor: |
Henderson, James W., Montebello, Annalisa, Grey, Joanna, Druce, Maralyn |
| Předmět: |
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| Zdroj: |
Clinical Endocrinology; Feb2023, Vol. 98 Issue 2, p221-228, 8p |
| Abstrakt: |
Objective: To investigate the impact of musculoskeletal (MSK)‐related symptoms on the quality of life of patients with multiple endocrine neoplasia Type 2b (MEN2B). Design: An online survey was distributed by the Association for Multiple Endocrine Neoplasia Disorders (AMEND) to their members and worldwide via a social media group for MEN2B patients. Methods: The survey consisted of a detailed questionnaire analysing the MSK‐related symptoms and structural deformities of MEN2B patients and their impact on patient's lives. Participants: Forty‐eight participants completed the survey. Results: Participants reported several musculoskeletal complaints; the most prevalent being musculoskeletal weakness at 73% (n = 35) and pain 58% (n = 28). The median pain score was 7 (interquartile range [IQR]: 5–8) and the frequency of pain was daily in 44% (n = 15) and constant in 21% (n = 7). Structural complaints were common with 63% (n = 30) stating their physique was 'different' and 40% (n = 19) describing marfanoid body features. Spinal curvature and foot deformities were the commonest structural abnormalities with scoliosis 70% (n = 16) and pes cavus 63% (n = 22) prevailing. Dental problems were mentioned by 69% (n = 33) with interdental spacing being the most common complaint at 61% (n = 20). The musculoskeletal symptoms of MEN2B had a median impact of 6 (IQR: 3–9) on quality of life (QOL) with structural deformities 53% (n = 18) and pain 26% (n = 9) listed as having the highest impact. Poor MSK health affected exercise, work and mobility. Conclusions: We report a high prevalence of musculoskeletal‐related complaints in MEN2B which significantly affects QOL. This suggests a need to provide better holistic care including a multidisciplinary team with physiotherapist, orthopaedic and dental specialist input. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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