| Autor: |
Teoh, Way Koon, Mohamed Sadiq, Nabeesathul Sumayya, Saisahas, Kasrin, Phonchai, Apichai, Kunalan, Vanitha, Md Muslim, Noor Zuhartini, Limbut, Warakorn, Abdullah, Ahmad Fahmi Lim, Chang, Kah Haw |
| Předmět: |
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| Zdroj: |
Journal of Forensic Sciences; Jan2023, Vol. 68 Issue 1, p75-85, 11p |
| Abstrakt: |
Drugs‐facilitated crimes (DFCs) involve the incapacitation of victims under the influence of drugs. Conventionally, a drug administration act is often determined through the examination of biological samples; however, dry residues from any surface, such as drinking glass if related to a DFC could be a potential source of evidence. This study was aimed to establish an attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR) spectroscopy coupled with chemometrics for the determination of spiked sedative‐hypnotics from dry residues of a drug‐spiked beverage. In this study, four sedative‐hypnotics, namely diazepam, ketamine, nimetazepam, and xylazine were examined using ATR‐FTIR spectroscopy. Subsequently, the ATR‐FTIR profiles were compared and decomposed by principal component analysis (PCA) followed by linear discriminant analysis (LDA) for their detection and discrimination. Visual comparison of ATR‐FTIR profiles revealed distinct spectra among the tested drugs. An initial unsupervised exploratory PCA model indicated the separation of four main sedative‐hypnotics clusters, and the proposed PCA score‐LDA model had allowed for a 100% accurate classification. Discrimination of sedative‐hypnotics from a dry beverage previously spiked with these drugs was also possible upon an additional extraction procedure. In conclusion, ATR‐FTIR coupled with PCA score‐LDA model was useful in detecting and discriminating sedative‐hypnotics, including those that had been previously spiked into a beverage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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