| Autor: |
Li, Yujie, Peng, Linjia, Zhang, Ke, Wu, Yong, Gao, Huifeng, Chen, Hao |
| Předmět: |
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| Zdroj: |
Journal of Inflammation Research; Oct2022, Vol. 15, p5977-5987, 11p |
| Abstrakt: |
aimed to establish a cytokine-based prognostic model for patients with PCLM who are receiving ablation. Patients and Methods: Serum samples from peripheral blood were collected from patients with PCLM before their first ablation. Cytokines were measured using Luminex chips and ELISA. Cox regression and least absolute shrinkage and selection operator regression were used to select prognostic factors for overall survival (OS). Area under the receiver operating characteristic curve (AUC) was applied to compare the ability to predict survival. Results: The relationship between cytokines and clinical factors was evaluated and their prognostic value was compared. Six optimal predictors were selected, including IL-2, IL-7, HGF, IFN-γ, CA19-9 and CEA. The risk model based on these predictors was built and named circulating tumor-associated inflammatory index (CTII). The CTII (AUCs > 0.90) showed superior performance to systemic immune-inflammation index (SII, AUCs < 0.65) in OS. Conclusion: A circulating cytokine-based risk model for patients with PCLM before first ablation has been proposed and validated, which has demonstrated superior performance in predicting survival and has the potential to inform clinical treatment strategies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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