Biochemical Markers as Predictor of Preterm Labor - and Their Clinical Relevance- the Current Status.
| Autor: | SINGH, Suneeta, DEY, Madhusudan, SINGH, Sanjay, SASIDHARAN, Shibu |
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| Předmět: |
RISK factors in premature labor
BIOMARKERS FIBRONECTINS INTERLEUKINS ALPHA fetoproteins ALKALINE phosphatase C-reactive protein PREMATURE infants CONNECTIVE tissue growth factor BLOOD proteins PROGESTERONE BODY fluids SERUM SALIVA FERRITIN AMNIOTIC liquid HIGH-risk pregnancy RISK assessment MATRIX metalloproteinases PROTEOMICS GLOBULINS VASCULAR endothelial growth factors GLUCOSE ESTRIOL |
| Zdroj: | Gynecology Obstetrics & Reproductive Medicine (MN GORM); 2022, Vol. 28 Issue 3, p282-289, 8p |
| Abstrakt: | Preterm birth is associated with significant perinatal morbidity and mortality. Spontaneous preterm birth accounts for up to 75% of all preterm births. Several maternal and fetal characteristics have been associated with preterm birth. With a better understanding of the pathophysiology of preterm birth, various biochemical markers have been studied extensively to predict preterm birth efficiently to intervene appropriately and timely in the cases that would benefit from treatment. This paper provides a summary of the current literature on the use of biochemical markers in predicting spontaneous preterm birth in symptomatic and high-risk-asymptomatic women. For this review, we searched the Cochrane, Medline, PubMed databases and we have included studies from 2009 to date mentioning these important markers in predicting preterm labor. Evidence from the literature suggests cervicovaginal fetal fibronectin, interleukin-6, phosphorylated Insulin-like growth factor binding protein-1, placental alpha macroglobulin-1, and serumα-fetoprotein are promising biochemical markers in predicting spontaneous preterm birth. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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