| Autor: |
Chen, Ruilin, Fu, Rong, Lin, Zeying, Huang, Chenghui, Huang, Wenhui |
| Předmět: |
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| Zdroj: |
Lupus; Jan2023, Vol. 32 Issue 1, p94-100, 7p, 1 Chart, 4 Graphs |
| Abstrakt: |
Objective: To investigate the efficacy and safety of telitacicept treatment in a Chinese SLE cohort, with real-life settings. Methods: All patients with SLE who were receiving telitacicept treatment at least 4 weeks were included, and were followed up. Patients received subcutaneous injection of telitacicept weekly based on the standard treatment. SLE responder index-4 (SRI-4) was assessed before the first administration and at least 4 weeks after the first administration. Disease flares during the follow-up period were defined as an increase in disease activity and the number or dose of immunosuppressive drugs. Results: After 4–45 weeks' administration of telitacicept, 80% (n = 16) reached SRI-4 response. The prednisolone dosage declined from a mean of 30.25 mg/d (95% CI 21.99–38.51) before treatment to 13.25 mg/d (95% CI 9.92–16.58) after treatment. The proportion of patients without receiving an immunosuppressive drug increased from 15% to 43% at the endpoint. 19 cases showed various reduction of IgM after treatment (p < 0.05) and C3 and C4 showed either stable or an upward trend. The 24 h urinary protein median value of the 14 cases (baseline 24 h urinary protein >0.5 g/d) showed significant reduction, and 7 of them turned negative. Adverse events were mild to moderate and controllable. Conclusion: Telitacicept is a potential treatment option for patients with SLE, especially in lupus nephritis, with significantly increased SRI-4 response rate and reduced the glucocorticoid and immunosuppressive drugs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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