| Autor: |
Buddhakala, Nopparat, Yongkhamcha, Butsara, Rattanaloeadnusorn, Sukhan, Talubmook, Chusri |
| Předmět: |
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| Zdroj: |
Trends in Sciences; Jan2023, Vol. 20 Issue 1, p1-11, 11p |
| Abstrakt: |
Syzygium aromaticum (L.) Merr. & Perry is a spice that has been used traditionally for centuries to preserve food and treat for a number of ailments. This research was carried out to analyze phytochemicals and to determine antidiabetic, antioxidant and anti-inflammatory activities of 95 % ethanol flower extract from S. aromaticum (FESA). The GC-MS analysis demonstrated the presence of 17 bioactive compounds in FESA, with eugenol (56.17 %) the most active compound. Antidiabetic activity study revealed that the inhibitory activity of the FESA against α-glucosidase enzyme was stronger than the activity of Acarbose, an antidiabetic drug. In addition, the FESA exhibited potent antioxidant activity by inhibiting 2, 2-diphenyl- 1-picrylhydrazylhydrate (DPPH) free radicals higher than butylated hydroxyltoluene (BHT), a synthetic antioxidant. Furthermore, the FESA potentially inhibited the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells but less effective than Diclofenac, a non-steroidal antiinflammatory drug. The activities of FESA are partly due to the presence of active compounds. The results obtained confirm the antidiabetic, antioxidant and anti-inflammatory properties, and the traditional used of S. aromaticum for the treatment of diabetes and oxidative and inflammatory-related diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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