| Autor: |
Vreijling, Sarah R., Penninx, Brenda W. J. H., Bot, Mariska, Watkins, Ed, Owens, Matthew, Kohls, Elisabeth, Hegerl, Ulrich, Roca, Miquel, Gili, Margalida, Brouwer, Ingeborg A., Visser, Marjolein, Beekman, Aartjan T. F., Jansen, Rick, Lamers, Femke |
| Předmět: |
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| Zdroj: |
Psychological Medicine; Nov2022, Vol. 52 Issue 15, p3580-3589, 10p |
| Abstrakt: |
Background: Dietary interventions did not prevent depression onset nor reduced depressive symptoms in a large multi-center randomized controlled depression prevention study (MooDFOOD) involving overweight adults with subsyndromal depressive symptoms. We conducted follow-up analyses to investigate whether dietary interventions differ in their effects on depressive symptom profiles (mood/cognition; somatic; atypical, energy-related). Methods: Baseline, 3-, 6-, and 12-month follow-up data from MooDFOOD were used (n = 933). Participants received (1) placebo supplements, (2) food-related behavioral activation (F-BA) therapy with placebo supplements, (3) multi-nutrient supplements (omega-3 fatty acids and a multi-vitamin), or (4) F-BA therapy with multi-nutrient supplements. Depressive symptom profiles were based on the Inventory of Depressive Symptomatology. Results: F-BA therapy was significantly associated with decreased severity of the somatic (B = −0.03, p = 0.014, d = −0.10) and energy-related (B = −0.08, p = 0.001, d = −0.13), but not with the mood/cognition symptom profile, whereas multi-nutrient supplementation was significantly associated with increased severity of the mood/cognition (B = 0.05, p = 0.022, d = 0.09) and the energy-related (B = 0.07, p = 0.002, d = 0.12) but not with the somatic symptom profile. Conclusions: Differentiating depressive symptom profiles indicated that food-related behavioral interventions are most beneficial to alleviate somatic symptoms and symptoms of the atypical, energy-related profile linked to an immuno-metabolic form of depression, although effect sizes were small. Multi-nutrient supplements are not indicated to reduce depressive symptom profiles. These findings show that attention to clinical heterogeneity in depression is of importance when studying dietary interventions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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